DEVELOPMENT OF CONJUGATE ADDITION OF LITHIUM DIALKYLCUPRATES TO THIOCHROMONES: SYNTHESIS OF 2-ALKYLTHIOCHROMAN-4-ONES AND ADDITIONAL SYNTHETIC APPLICATIONS

Lithium dialkylcuprates undergo conjugate addition to thiochromones to afford 2-alkylthiochroman-4-ones in good yields.This approach provide an efficient and general synthetic approach to privileged sulfur-containing structural motifs and valuable stirrup extender western precursors for many pharmaceuticals, starting from common substrates-thiochro

Dog-strangling vine (Vincetoxicum rossicum) is an exotic plant originating from Central and Eastern Europe that is becoming increasingly invasive in southern Ontario, copyright.Once established, it successfully displaces local native plant species but mechanisms behind this plant’s high competitive ability are not fully bl2420pt understood.It

Silver is a known disinfectant from ancient times, and it has been widely used for various purposes: for food and water disinfection, curing of wounds and as a universal antibiotic for a wide spectrum of diseases - until the Second World War and the discovery of penicillin.Until recently, it was assumed that silver, being a heavy metal, was toxic f